SWAP70

SWAP70 (Switching B Cell Complex Subunit SWAP70) is a Protein Coding gene. Diseases associated with SWAP70 include Common Variable Immunodeficiency. Among its related pathways are NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is DEF6.Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

SWAP70

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

Biological Process actin filament bundle assemblyIEA:Ensembl
Biological Process isotype switchingIEA:Ensembl
Biological Process negative regulation of actin filament depolymerizationIEA:Ensembl
Biological Process negative regulation of cell-cell adhesion mediated by integrinIEA:Ensembl
Biological Process negative regulation of peptidyl-serine dephosphorylationIEA:Ensembl
Biological Process positive regulation of actin filament bundle assemblyIEA:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Biological Process positive regulation of mast cell chemotaxisIEA:Ensembl
Biological Process regulation of protein localizationIEA:Ensembl
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome

Cytoplasm
Cell membrane
Nucleus
Cell projection, lamellipodium
Cytoplasm, cytoskeleton
In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448).
In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448).
Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760).

Tyrosine-phosphorylated.