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Mouse Anti-SWAP70 Recombinant Antibody (CBXS-0895) (CBMAB-S3814-CQ)

This product is a mouse antibody that recognizes SWAP70. The antibody CBXS-0895 can be used for immunoassay techniques such as: S-ELISA, ELISA, WB, IHC-P.
See all SWAP70 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXS-0895
Antibody Isotype
IgG2a, κ
Application
S-ELISA, ELISA, WB, IHC-P

Basic Information

Immunogen
SWAP70 (NP_055870, 378 a.a.-451 a.a) partial recombinant protein with GST tag
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SWAP70
Introduction
SWAP70 (Switching B Cell Complex Subunit SWAP70) is a Protein Coding gene. Diseases associated with SWAP70 include Common Variable Immunodeficiency. Among its related pathways are NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is DEF6.Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Entrez Gene ID
Human23075
Mouse20947
Rat293410
UniProt ID
HumanQ9UH65
MouseQ6A028
RatD3ZRE7
Alternative Names
HSPC321; SWAP-70
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Biological Process
Biological Process actin filament bundle assemblyIEA:Ensembl
Biological Process isotype switchingIEA:Ensembl
Biological Process negative regulation of actin filament depolymerizationIEA:Ensembl
Biological Process negative regulation of cell-cell adhesion mediated by integrinIEA:Ensembl
Biological Process negative regulation of peptidyl-serine dephosphorylationIEA:Ensembl
Biological Process positive regulation of actin filament bundle assemblyIEA:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Biological Process positive regulation of mast cell chemotaxisIEA:Ensembl
Biological Process regulation of protein localizationIEA:Ensembl
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Cellular Location
Cytoplasm
Cell membrane
Nucleus
Cell projection, lamellipodium
Cytoplasm, cytoskeleton
In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448).
In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448).
Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760).
PTM
Tyrosine-phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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