Sign in or Register   Sign in or Register
  |  

Mouse Anti-SWAP70 Recombinant Antibody (2E9-E8-E9) (CBMAB-Z0260-LY)

The product is antibody recognizes SWAP70. The antibody 2E9-E8-E9 immunoassay techniques such as: WB, IP.
See all SWAP70 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Monkey
Clone
2E9-E8-E9
Antibody Isotype
IgG2b
Application
WB, IP

Basic Information

Immunogen
Purified recombinant human SWAP70 protein fragments expressed in E.coli.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites containing with 0.03% Proclin300 and 50% glycerol.
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SWAP70
Entrez Gene ID
Human23075
Mouse20947
Rat293410
Monkey703651
UniProt ID
HumanQ9UH65
MouseQ6A028
RatD3ZRE7
MonkeyF7HJZ8
Alternative Names
HSPC321; SWAP-70; FLJ39540; KIAA0640
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Biological Process
Biological Process actin filament bundle assemblyIEA:Ensembl
Biological Process isotype switchingIEA:Ensembl
Biological Process negative regulation of actin filament depolymerizationIEA:Ensembl
Biological Process negative regulation of cell-cell adhesion mediated by integrinIEA:Ensembl
Biological Process negative regulation of peptidyl-serine dephosphorylationIEA:Ensembl
Biological Process positive regulation of actin filament bundle assemblyIEA:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Biological Process positive regulation of mast cell chemotaxisIEA:Ensembl
Biological Process regulation of protein localizationIEA:Ensembl
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Cellular Location
Cytoplasm
Cell membrane
Nucleus
Cell projection, lamellipodium
Cytoplasm, cytoskeleton
In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448).
In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448).
Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760).
PTM
Tyrosine-phosphorylated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SWAP70 Recombinant Antibody (2E9-E8-E9)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare