Mouse Anti-SWAP70 Recombinant Antibody (CBXS-0891) (CBMAB-S3810-CQ)

Name: Mouse Anti-SWAP70 Recombinant Antibody (CBXS-0891)
SKU: CBMAB-S3810-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-0891

Application

WB, ELISA

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SWAP70

Introduction

SWAP70 (Switching B Cell Complex Subunit SWAP70) is a Protein Coding gene. Diseases associated with SWAP70 include Common Variable Immunodeficiency. Among its related pathways are NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is DEF6.Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

Entrez Gene ID

Human	23075
Mouse	20947
Rat	293410

UniProt ID

Human	Q9UH65
Mouse	Q6A028
Rat	D3ZRE7

Alternative Names

HSPC321; SWAP-70

Function

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

Biological Process

Biological Process actin filament bundle assemblyIEA:Ensembl
Biological Process isotype switchingIEA:Ensembl
Biological Process negative regulation of actin filament depolymerizationIEA:Ensembl
Biological Process negative regulation of cell-cell adhesion mediated by integrinIEA:Ensembl
Biological Process negative regulation of peptidyl-serine dephosphorylationIEA:Ensembl
Biological Process positive regulation of actin filament bundle assemblyIEA:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Biological Process positive regulation of mast cell chemotaxisIEA:Ensembl
Biological Process regulation of protein localizationIEA:Ensembl
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome

Cellular Location

Cytoplasm
Cell membrane
Nucleus
Cell projection, lamellipodium
Cytoplasm, cytoskeleton
In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448).
In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448).
Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760).

PTM

Tyrosine-phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

SWAP70 Matched Antibody Pair (1173) (CAT#: APMAB-1173LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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