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Mouse Anti-SYNM Recombinant Antibody (2F4) (CBMAB-D2259-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Synemin (SYNM). The antibody can be used for immunoassay techniques, such as IHC-P.
See all SYNM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F4
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 329-580

Target

Full Name
Synemin
Introduction
SYNM is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. SYNM has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle.
Entrez Gene ID
23336
UniProt ID
O15061
Alternative Names
DMN; SYN
Function
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
Biological Process
Biological Process fast-twitch skeletal muscle fiber contractionIBA:GO_Central1 Publication
Biological Process intermediate filament cytoskeleton organizationTAS:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, adherens junction
There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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