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SYNM

The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene.
Full Name
Synemin
Function
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
Biological Process
Biological Process fast-twitch skeletal muscle fiber contractionIBA:GO_Central1 Publication
Biological Process intermediate filament cytoskeleton organizationTAS:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, adherens junction
There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere.
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Anti-SYNM antibodies

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Mouse Anti-SYNM Recombinant Antibody (CBXS-3248) (CBMAB-S5989-CQ)

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Target: SYNM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3248
Application*: E, WB
Datasheet SDS

Mouse Anti-SYNM Recombinant Antibody (CBXS-4830) (CBMAB-S2054-CQ)

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Target: SYNM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4830
Application*: WB, IH
Datasheet SDS

Mouse Anti-SYNM Recombinant Antibody (CBXS-4585) (CBMAB-S1825-CQ)

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Target: SYNM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4585
Application*: P
Datasheet SDS

Mouse Anti-SYNM Recombinant Antibody (7H6) (CBMAB-D2263-YC)

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Target: SYNM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H6
Application*: P, WB
Datasheet SDS

Mouse Anti-SYNM Recombinant Antibody (7A9) (CBMAB-D2262-YC)

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Target: SYNM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7A9
Application*: P, WB
Datasheet SDS

Mouse Anti-SYNM Recombinant Antibody (V2-34151) (CBMAB-D2261-YC)

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Target: SYNM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-34151
Application*: P
Datasheet SDS

Mouse Anti-SYNM Recombinant Antibody (3D10) (CBMAB-D2260-YC)

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Target: SYNM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D10
Application*: P, WB
Datasheet SDS

Mouse Anti-SYNM Recombinant Antibody (2F4) (CBMAB-D2259-YC)

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Target: SYNM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F4
Application*: P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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