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Mouse Anti-SYT3 Recombinant Antibody (S278-19) (CBMAB-S0023-CQ)

This product is a mouse antibody that recognizes SYT3. The antibody S278-19 can be used for immunoassay techniques such as: WB, IF.
See all SYT3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S278-19
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Fusion protein amino acids 442-533 (Cytoplasmic C2B domain) of mouse Synaptotagmin-3
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Synaptotagmin 3
Introduction
SYT3 (Synaptotagmin 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT10.Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Entrez Gene ID
Human84258
Mouse20981
Rat25731
UniProt ID
HumanQ9BQG1
MouseO35681
RatP40748
Alternative Names
SytIII
Function
Ca2+ sensor involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain. Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).
Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process positive regulation of dendrite extensionIDA:UniProtKB1 Publication
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication
Cellular Location
Cell membrane
Cytoplasmic vesicle, secretory vesicle membrane
Topology
Vesicular: 1-54
Helical: 55-75
Cytoplasmic: 76-590
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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