SYT3

SYT3 (Synaptotagmin 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT10.Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Full Name

Synaptotagmin 3

Function

Ca2+ sensor involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain. Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).
Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Biological Process

Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process positive regulation of dendrite extensionIDA:UniProtKB1 Publication
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication

Cellular Location

Cell membrane
Cytoplasmic vesicle, secretory vesicle membrane

Topology

Vesicular: 1-54
Helical: 55-75
Cytoplasmic: 76-590