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Mouse Anti-TAF11 Recombinant Antibody (CBYJT-1828) (CBMAB-T0892-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAF11 (TATA-Box Binding Protein Associated Factor 11). The antibody can be used for immunoassay techniques, such as ELISA, WB, ICC, IP.
See all TAF11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1828
Antibody Isotype
IgG1, κ
Application
ELISA, WB, ICC, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
Introduction
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF11 is a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure.
Entrez Gene ID
6882
UniProt ID
Q15544
Alternative Names
TATA-Box Binding Protein Associated Factor 11; TAF11 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 28kDa; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, I, 28kD; Transcription Initiation Factor TFIID 28 KDa Subunit; TFIID Subunit P30-Beta; TAF(II)28; TAFII-28
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).
TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).
The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).
TAF11, together with TAF13 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes (PubMed:33795473).
Biological Process
Biological Process mRNA transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process positive regulation by host of viral transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of transcription initiation by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein phosphorylationIDA:ComplexPortal1 Publication
Biological Process RNA polymerase II preinitiation complex assemblyIPI:ComplexPortal1 Publication
Biological Process transcription by RNA polymerase IIIC:UniProtKB1 Publication
Biological Process transcription initiation at RNA polymerase II promoterIC:UniProtKB1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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