Mouse Anti-TAF4B Recombinant Antibody (CBYJT-1874) (CBMAB-T0944-YJ)

Name: Mouse Anti-TAF4B Recombinant Antibody (CBYJT-1874)
SKU: CBMAB-T0944-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-1874

Application

ELISA, ICC, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TATA-Box Binding Protein Associated Factor 4b

Introduction

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. TAF4B is a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells.

Entrez Gene ID

6875

UniProt ID

Q92750

Alternative Names

TATA-Box Binding Protein Associated Factor 4b; TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 105kDa; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C2, 105kD; Transcription Initiation Factor TFIID 105 KDa Subunit; TATA Box Binding Protein (TBP)-Associated Factor 4B; TAF(II)105

Function

Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.

Biological Process

Biological Process mRNA transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process oogenesisIEA:UniProtKB-KW
Biological Process positive regulation of transcription initiation by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein phosphorylationIDA:ComplexPortal1 Publication
Biological Process spermatogenesisIEA:UniProtKB-KW
Biological Process transcription initiation at RNA polymerase II promoterIBA:GO_Central1 Publication

Cellular Location

Nucleus
Cytoplasm
Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.

Involvement in disease

Spermatogenic failure 13 (SPGF13):
A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.

PTM

Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TAF4B Recombinant Antibody (TAFAD26A) (CAT#: CBMAB-T0943-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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