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Mouse Anti-TAF4B Recombinant Antibody (CBYJT-1874) (CBMAB-T0944-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAF4B (TATA-Box Binding Protein Associated Factor 4b). The antibody can be used for immunoassay techniques, such as ELISA, ICC, WB.
See all TAF4B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1874
Antibody Isotype
IgG1
Application
ELISA, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TATA-Box Binding Protein Associated Factor 4b
Introduction
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. TAF4B is a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells.
Entrez Gene ID
6875
UniProt ID
Q92750
Alternative Names
TATA-Box Binding Protein Associated Factor 4b; TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 105kDa; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C2, 105kD; Transcription Initiation Factor TFIID 105 KDa Subunit; TATA Box Binding Protein (TBP)-Associated Factor 4B; TAF(II)105
Function
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.
Biological Process
Biological Process mRNA transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process oogenesisIEA:UniProtKB-KW
Biological Process positive regulation of transcription initiation by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein phosphorylationIDA:ComplexPortal1 Publication
Biological Process spermatogenesisIEA:UniProtKB-KW
Biological Process transcription initiation at RNA polymerase II promoterIBA:GO_Central1 Publication
Cellular Location
Nucleus
Cytoplasm
Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.
Involvement in disease
Spermatogenic failure 13 (SPGF13):
A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.
PTM
Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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