TAF4B

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. TAF4B is a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells.

Full Name

TATA-Box Binding Protein Associated Factor 4b

Function

Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.

Biological Process

Biological Process mRNA transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process oogenesisIEA:UniProtKB-KW
Biological Process positive regulation of transcription initiation by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein phosphorylationIDA:ComplexPortal1 Publication
Biological Process spermatogenesisIEA:UniProtKB-KW
Biological Process transcription initiation at RNA polymerase II promoterIBA:GO_Central1 Publication

Cellular Location

Nucleus
Cytoplasm
Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.

Involvement in disease

Spermatogenic failure 13 (SPGF13):
A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.

PTM

Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).