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Mouse Anti-TAF5L Recombinant Antibody (CBYJT-1881) (CBMAB-T0952-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAF5L (TATA-Box Binding Protein Associated Factor 5 Like). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TAF5L antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1881
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-118 from human TAF5L (NP_055224) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-118

Target

Full Name
TATA-Box Binding Protein Associated Factor 5 Like
Introduction
TAF5L belongs to the WD-repeat TAF5 family of proteins. TAF5L is a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. TAF5L is structurally similar to one of the histone-like TAFs, TAF5.
Entrez Gene ID
27097
UniProt ID
O75529
Alternative Names
TATA-Box Binding Protein Associated Factor 5 Like; TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa; PCAF-Associated Factor 65 Beta; PAF65-Beta; PAF65B; TAF5-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor 65 KDa Subunit 5L; TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65 KD; PCAF Associated Factor 65 Beta
Function
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity).
Biological Process
Biological Process histone acetylationIBA:GO_Central1 Publication
Biological Process histone H3 acetylationIDA:UniProtKB1 Publication
Biological Process monoubiquitinated histone deubiquitinationIDA:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitinationIDA:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcriptionIC:ComplexPortal1 Publication
Biological Process regulation of DNA repairIC:ComplexPortal2 Publications
Biological Process regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process regulation of RNA splicingIC:ComplexPortal1 Publication
Biological Process regulation of somatic stem cell population maintenanceISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process transcription by RNA polymerase IITAS:ProtInc1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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