TAF5L

TAF5L belongs to the WD-repeat TAF5 family of proteins. TAF5L is a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. TAF5L is structurally similar to one of the histone-like TAFs, TAF5.

Full Name

TATA-Box Binding Protein Associated Factor 5 Like

Function

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity).

Biological Process

Biological Process histone acetylationIBA:GO_Central1 Publication
Biological Process histone H3 acetylationIDA:UniProtKB1 Publication
Biological Process monoubiquitinated histone deubiquitinationIDA:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitinationIDA:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcriptionIC:ComplexPortal1 Publication
Biological Process regulation of DNA repairIC:ComplexPortal2 Publications
Biological Process regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process regulation of RNA splicingIC:ComplexPortal1 Publication
Biological Process regulation of somatic stem cell population maintenanceISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process transcription by RNA polymerase IITAS:ProtInc1 Publication

Cellular Location

Nucleus