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Mouse Anti-TAF9B Recombinant Antibody (CBYJT-1899) (CBMAB-T0972-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAF9B (TATA-Box Binding Protein Associated Factor 9b). The antibody can be used for immunoassay techniques, such as ICC, WB.
See all TAF9B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1899
Antibody Isotype
IgG2b
Application
ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TATA-Box Binding Protein Associated Factor 9b
Introduction
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF9B is a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process.
Entrez Gene ID
UniProt ID
Alternative Names
TATA-Box Binding Protein Associated Factor 9b; TAF9-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa; TAF9B RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa; Transcription-Associated Factor TAFII31L; Neuronal Cell Death-Related Protein 7; TAF9L; DN-7; Transcription Initiation Factor TFIID Subunit 9-Like
Function
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.
Biological Process
Biological Process DNA-templated transcription initiationIEA:InterPro
Biological Process negative regulation of apoptotic processIMP:BHF-UCL2 Publications
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIC:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase IIIMP:BHF-UCL1 Publication
Biological Process positive regulation of cell growthIMP:UniProtKB1 Publication
Biological Process protein stabilizationIDA:BHF-UCL1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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