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Mouse Anti-TAGLN Recombinant Antibody (SMP22a) (CBMAB-S6571-CQ)

This product is a mouse antibody that recognizes TAGLN. The antibody SMP22a can be used for immunoassay techniques such as: IHC-P, IF.
See all TAGLN antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
SMP22a
Antibody Isotype
IgG1, κ
Application
IHC-P, IF

Basic Information

Immunogen
Recombinant Full length human protein
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1 mg/mL BSA
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TAGLN Gene(Protein Coding) Transgelin
Introduction
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.
Entrez Gene ID
Human6876
Mouse21345
UniProt ID
HumanQ01995
MouseP37804
Alternative Names
Transgelin; SM22-Alpha; Smooth Muscle Protein 22-Alpha; 22 KDa Actin-Binding Protein; Transgelin Variant 2; WS3-10;
Function
Actin cross-linking/gelling protein (By similarity).
Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Biological Process
Biological Process epithelial cell differentiationIDA:UniProtKB1 Publication
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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