TAGLN
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
Full Name
TAGLN Gene(Protein Coding) Transgelin
Function
Actin cross-linking/gelling protein (By similarity).
Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Biological Process
Biological Process epithelial cell differentiationIDA:UniProtKB1 Publication
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Cellular Location
Cytoplasm
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Anti-TAGLN antibodies
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CompareTarget: TAGLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Rat
Clone: CBYJT-1914
Application*: E, WB, IH
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-1909
Application*: E, WB
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-1908
Application*: E, WB
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF422
Application*: ELISA, WB, IHC
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B11
Application*: WB, E
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3A3
Application*: WB, E
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1D11
Application*: WB, E
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C4
Application*: E, E
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E2
Application*: WB, E
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: SMP22a
Application*: P, IF
Target: TAGLN
Host: Mouse
Specificity: Human
Clone: CBXS-0927
Application*: WB, IC, P, C, E
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: CBXS-5855
Application*: IH, WB
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5828
Application*: E
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG
Specificity: Pig, Rat, Human, Cattle, Mouse
Clone: CBYJT-1915
Application*: WB, IF, E
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Pig, Rabbit
Clone: SPM606
Application*: F, P, IF, MC
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBYJT-1913
Application*: WB, IH, IC, IF, P
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-1912
Application*: IF, P
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1911
Application*: WB, IC
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-1910
Application*: E
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-1907
Application*: E, WB
Target: TAGLN
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11BA42
Application*: E, WB
Target: TAGLN
Specificity: Human
Target: TAGLN
Specificity: Human
Target: TAGLN
Specificity: Human
Target: TAGLN
Specificity: Human
Target: TAGLN
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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