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Mouse Anti-Tarm1 Recombinant Antibody (CBYJT-2004) (CBMAB-T1095-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Tarm1 (T Cell-Interacting, Activating Receptor On Myeloid Cells 1). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all Tarm1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBYJT-2004
Antibody Isotype
IgM
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 237-259 near the C-terminus of TARM1 of mouse origin
Specificity
Mouse, Rat
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/mL
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
T Cell-Interacting, Activating Receptor On Myeloid Cells 1
Introduction
Tarm1 may act as receptor. It negatively regulates TCR-mediated CD4+ T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface. Tarm1 enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils.
Entrez Gene ID
Mouse245126
Rat499065
UniProt ID
MouseB6A8R8
RatD3ZW99
Alternative Names
OLT-2; Gm9904; 9930022N03Rik
Function
May act as receptor (By similarity).
Negatively regulates TCR-mediated CD4+ T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface (PubMed:26311901).
Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils (By similarity).
Biological Process
Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process negative regulation of CD4-positive, alpha-beta T cell activationIDA:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 17-236
Helical: 237-257
Cytoplasmic: 237-257
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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