TARM1

Tarm1 may act as receptor. It negatively regulates TCR-mediated CD4+ T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface. Tarm1 enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils.

Full Name

T Cell-Interacting, Activating Receptor On Myeloid Cells 1

Function

May act as receptor (By similarity).
Negatively regulates TCR-mediated CD4+ T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface (PubMed:26311901).
Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils (By similarity).

Biological Process

Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process negative regulation of CD4-positive, alpha-beta T cell activationIDA:UniProtKB1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 17-236
Helical: 237-257
Cytoplasmic: 237-257

PTM

N-glycosylated.