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Mouse Anti-TBC1D2B Recombinant Antibody (CBYJT-2049) (CBMAB-T1145-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBC1D2B (TBC1 Domain Family Member 2B). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TBC1D2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2049
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TBC1 Domain Family Member 2B
Introduction
TBC1D2B (TBC1 Domain Family Member 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to TBC1D2B include GTPase activator activity. An important paralog of TBC1D2B is TBC1D2.
Entrez Gene ID
23102
UniProt ID
Q9UPU7
Alternative Names
TBC1 Domain Family Member 2B; TBC1 Domain Family, Member 2B; KIAA1055
Function
GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794).
Biological Process
Biological Process activation of GTPase activityIBA:GO_Central1 Publication
Biological Process endocytosisIMP:UniProtKB1 Publication
Cellular Location
Early endosome
Involvement in disease
Neurodevelopmental disorder with seizures and gingival overgrowth (NEDSGO):
An autosomal recessive disorder with variable clinical manifestations including delayed development, hypotonia, seizures, gingival hypertrophy associated with a prominent mandible or cherubism in the first years of life. Some patients have early normal development followed by developmental regression. Additional variable features are coarse facial features, optic atrophy, sensorineural hearing loss, and ataxia. Brain imaging may show cerebellar or cerebral atrophy and enlarged ventricles.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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