Mouse Anti-TBC1D2B Recombinant Antibody (CBYJT-2050) (CBMAB-T1146-YJ)

Name: Mouse Anti-TBC1D2B Recombinant Antibody (CBYJT-2050)
SKU: CBMAB-T1146-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2050

Application

WB, IP, IF, ELISA

Immunogen

Specific for an epitope mapping between amino acids 591-610 within an internal region of TBC1D2B of human origin

Specificity

Human, Rat, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 591-610

More Infomation

Target

Full Name

TBC1 Domain Family Member 2B

Introduction

TBC1D2B (TBC1 Domain Family Member 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to TBC1D2B include GTPase activator activity. An important paralog of TBC1D2B is TBC1D2.

Entrez Gene ID

Human	23102
Mouse	67016
Rat	315880

UniProt ID

Human	Q9UPU7
Mouse	Q3U0J8
Rat	D3ZAF7

Alternative Names

TBC1 Domain Family Member 2B; TBC1 Domain Family, Member 2B; KIAA1055

Function

GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794).

Biological Process

Biological Process activation of GTPase activityIBA:GO_Central1 Publication
Biological Process endocytosisIMP:UniProtKB1 Publication

Cellular Location

Early endosome

Involvement in disease

Neurodevelopmental disorder with seizures and gingival overgrowth (NEDSGO):
An autosomal recessive disorder with variable clinical manifestations including delayed development, hypotonia, seizures, gingival hypertrophy associated with a prominent mandible or cherubism in the first years of life. Some patients have early normal development followed by developmental regression. Additional variable features are coarse facial features, optic atrophy, sensorineural hearing loss, and ataxia. Brain imaging may show cerebellar or cerebral atrophy and enlarged ventricles.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TBC1D2B Recombinant Antibody (CBYJT-2049) (CAT#: CBMAB-T1145-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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