Mouse Anti-TBCB Recombinant Antibody (CBYJT-2064) (CBMAB-T1161-YJ)

Name: Mouse Anti-TBCB Recombinant Antibody (CBYJT-2064)
SKU: CBMAB-T1161-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2064

Application

ELISA, WB

Immunogen

Recombinant protein corresponding to aa1-244 from human TBCB expressed in E. coli

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 10% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-244

More Infomation

Target

Full Name

TBCB Gene(Protein Coding) Tubulin Folding Cofactor B

Introduction

TBCB (Tubulin Folding Cofactor B) is a Protein Coding gene. Diseases related to TBCB include Hypoparathyroidism-Retardation-Dysmorphism Syndrome. Among its related pathways are Metabolism of proteins and Chaperonin-mediated protein folding. An important paralog of TBCB is CLIP2.

Entrez Gene ID

1155

UniProt ID

Q99426

Alternative Names

Tubulin Folding Cofactor B; Cytoskeleton-Associated Protein CKAPI; Cytoskeleton-Associated Protein 1; Cytoskeleton Associated Protein 1; Tubulin-Specific Chaperone B; CKAP1; CG22; Tubulin-Folding Cofactor B; CKAPI

Function

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649).
Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).

Biological Process

Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nervous system developmentIEA:UniProtKB-KW

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton
Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.

PTM

Phosphorylation by PAK1 is required for normal function.
Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome.
(Microbial infection) Glycosylated residues by S.typhimurium protein Ssek1: arginine GlcNAcylation promotes microtubule stability.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-TBCB Recombinant Antibody (AT1F6) (CAT#: CBMAB-1829-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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