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TBCB

TBCB (Tubulin Folding Cofactor B) is a Protein Coding gene. Diseases associated with TBCB include Hypoparathyroidism-Retardation-Dysmorphism Syndrome. Among its related pathways are Metabolism of proteins and Chaperonin-mediated protein folding. An important paralog of this gene is CLIP2.

Full Name

TBCB Gene(Protein Coding) Tubulin Folding Cofactor B

Function

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649).
Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).

Biological Process

Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nervous system developmentIEA:UniProtKB-KW

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton
Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.

PTM

Phosphorylation by PAK1 is required for normal function.
Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome.
(Microbial infection) Glycosylated residues by S.typhimurium protein Ssek1: arginine GlcNAcylation promotes microtubule stability.

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Anti-TBCB antibodies

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Mouse Anti-TBCB Recombinant Antibody (CBXC-2000) (CBMAB-C0071-CQ)

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Target: TBCB

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXC-2000

Application*: WB, E

Mouse Anti-TBCB Recombinant Antibody (CBYJT-2064) (CBMAB-T1161-YJ)

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Target: TBCB

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-2064

Application*: E, WB

Mouse Anti-TBCB (AA 1-244) Recombinant Antibody (CBFYC-0400) (CBMAB-C0441-FY)

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Target: TBCB

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-0400

Application*: WB, E

Mouse Anti-TBCB Recombinant Antibody (AT1F6) (CBMAB-1829-CN)

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Target: TBCB

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: AT1F6

Application*: WB

Human Recombinant TBCB protein, His Tag (V2LY-0526-LY3148)

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Target: TBCB

Expressed Host: E. coli

Sequence: Amino Acid: 1-244

Tag: His Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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