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Mouse Anti-TBR1 Recombinant Antibody (CBYJT-2123) (CBMAB-T1225-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBR1 (T-Box, Brain 1). The antibody can be used for immunoassay techniques, such as S-ELISA, IF, ELISA, WB.
See all TBR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2123
Antibody Isotype
IgG2a, κ
Application
S-ELISA, IF, ELISA, WB

Basic Information

Immunogen
TBR1 (NP_006584, 1 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-108

Target

Full Name
TBR1 Gene(Protein Coding) T-Box, Brain 1
Introduction
TBR1 is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of TBR1 is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of TBR1 was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
Entrez Gene ID
10716
UniProt ID
Q16650
Alternative Names
T-Box, Brain 1; T-Brain-1; TES-56; TBR-1; T-Box Brain Protein 1; T-Box, Brain, 1
Function
Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039).
As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).
Biological Process
Biological Process amygdala developmentIEA:Ensembl
Biological Process brain developmentTAS:ProtInc1 Publication
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process cerebral cortex developmentIEA:Ensembl
Biological Process chromatin remodelingIEA:Ensembl
Biological Process commitment of neuronal cell to specific neuron type in forebrainIBA:GO_Central1 Publication
Biological Process conditioned taste aversionIEA:Ensembl
Biological Process hindbrain developmentIEA:Ensembl
Biological Process histone deacetylationIEA:Ensembl
Biological Process negative regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of axon guidanceIEA:Ensembl
Biological Process regulation of neuron projection developmentIBA:GO_Central1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process specification of animal organ identityIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Intellectual developmental disorder with autism and speech delay (IDDAS):
An autosomal dominant neurodevelopmental disorder characterized by varying degrees of intellectual disability, autism spectrum disorder, and language deficits.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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