Mouse Anti-TBR1 Recombinant Antibody (CBYJT-2123) (CBMAB-T1225-YJ)

Name: Mouse Anti-TBR1 Recombinant Antibody (CBYJT-2123)
SKU: CBMAB-T1225-YJ
Rating: 5 (1 reviews)

See all TBR1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-2123

Application

S-ELISA, IF, ELISA, WB

Immunogen

TBR1 (NP_006584, 1 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-108

More Infomation

Target

Full Name

TBR1 Gene(Protein Coding) T-Box, Brain 1

Introduction

TBR1 is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of TBR1 is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of TBR1 was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.

Entrez Gene ID

10716

UniProt ID

Q16650

Alternative Names

T-Box, Brain 1; T-Brain-1; TES-56; TBR-1; T-Box Brain Protein 1; T-Box, Brain, 1

Function

Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039).
As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).

Biological Process

Biological Process amygdala developmentIEA:Ensembl
Biological Process brain developmentTAS:ProtInc1 Publication
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process cerebral cortex developmentIEA:Ensembl
Biological Process chromatin remodelingIEA:Ensembl
Biological Process commitment of neuronal cell to specific neuron type in forebrainIBA:GO_Central1 Publication
Biological Process conditioned taste aversionIEA:Ensembl
Biological Process hindbrain developmentIEA:Ensembl
Biological Process histone deacetylationIEA:Ensembl
Biological Process negative regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of axon guidanceIEA:Ensembl
Biological Process regulation of neuron projection developmentIBA:GO_Central1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process specification of animal organ identityIEA:Ensembl

Cellular Location

Nucleus

Involvement in disease

Intellectual developmental disorder with autism and speech delay (IDDAS):
An autosomal dominant neurodevelopmental disorder characterized by varying degrees of intellectual disability, autism spectrum disorder, and language deficits.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-TBR1 Recombinant Antibody (CBYJT-2123)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-TBR1 Recombinant Antibody (
2E10) (CAT#: V2LY-0725-LY1310)

Mouse Anti-TBR1 Recombinant Antibody (CBYJT-2122) (CAT#: CBMAB-T1224-YJ)

Mouse Anti-TBR1 Recombinant Antibody (3F6) (CAT#: CBMAB-A8902-LY)

Mouse Anti-Tbr1 Recombinant Antibody (CBYJT-2125) (CAT#: CBMAB-T1227-YJ)

Rabbit Anti-TBR1 Recombinant Antibody (CBNH-097) (CAT#: CBMAB-R4422-CN)

Rabbit Anti-TBR1 Recombinant Antibody (D6C6X) (CAT#: CBMAB-CP2715-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry