Sign in or Register   Sign in or Register
  |  

Rabbit Anti-TBR1 Recombinant Antibody (D6C6X) (CBMAB-CP2715-LY)

The product is antibody recognizes TBR1. The antibody D6C6X immunoassay techniques such as: IHC-P,IF.
See all TBR1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D6C6X
Antibody Isotype
IgG
Application
IHC-P, IF

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro415 of human TBR1 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TBR1 Gene(Protein Coding) T-Box, Brain 1
Introduction
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015]
Entrez Gene ID
Human10716
Mouse21375
Rat680427
UniProt ID
HumanQ16650
MouseQ64336
RatD4A6N8
Alternative Names
T-Box; Brain 1; T-Brain-1; TES-56; TBR-1; T-Box Brain Protein 1; T-Box; Brain; 1;
Function
Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039).
As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).
Biological Process
Biological Process amygdala developmentIEA:Ensembl
Biological Process brain developmentTAS:ProtInc1 Publication
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process cerebral cortex developmentIEA:Ensembl
Biological Process chromatin remodelingIEA:Ensembl
Biological Process commitment of neuronal cell to specific neuron type in forebrainIBA:GO_Central1 Publication
Biological Process conditioned taste aversionIEA:Ensembl
Biological Process hindbrain developmentIEA:Ensembl
Biological Process histone deacetylationIEA:Ensembl
Biological Process negative regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of axon guidanceIEA:Ensembl
Biological Process regulation of neuron projection developmentIBA:GO_Central1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process specification of animal organ identityIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Intellectual developmental disorder with autism and speech delay (IDDAS):
An autosomal dominant neurodevelopmental disorder characterized by varying degrees of intellectual disability, autism spectrum disorder, and language deficits.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-TBR1 Recombinant Antibody (D6C6X)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare