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Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2181) (CBMAB-T1286-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBXAS1 (Thromboxane A Synthase 1). The antibody can be used for immunoassay techniques, such as ICC, IF, IHC, IHC-P, WB.
See all TBXAS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2181
Antibody Isotype
IgG2a
Application
ICC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human TXA synthase (NP_001052) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Thromboxane A Synthase 1
Introduction
TBXAS1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, TBXAS1 is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. TBXAS1 plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke.
Entrez Gene ID
6916
UniProt ID
P24557
Alternative Names
Thromboxane A Synthase 1; Cytochrome P450, Family 5, Subfamily A, Polypeptide 1; Thromboxane A Synthase 1 (Platelet); Cytochrome P450 5A1; TXA Synthase; EC 5.3.99.5; CYP5A1; CYP5; TXS
Function
Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:8436233, PubMed:11297515, PubMed:9873013, PubMed:11097184, PubMed:24009185, PubMed:22735388).
Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:9873013, PubMed:22735388).
Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323).
Biological Process
Biological Process cellular chloride ion homeostasisIEA:Ensembl
Biological Process cyclooxygenase pathwayTAS:Reactome
Biological Process icosanoid metabolic processIDA:UniProtKB1 Publication
Biological Process positive regulation of vasoconstrictionIEA:Ensembl
Biological Process prostaglandin biosynthetic processIMP:UniProtKB1 Publication
Biological Process response to ethanolIEA:Ensembl
Biological Process response to fatty acidIEA:Ensembl
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Ghosal hematodiaphyseal dysplasia (GHDD):
Rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
Topology
Cytoplasmic: 1-10
Helical: 11-31
Lumenal: 32-75
Helical: 76-96
Cytoplasmic: 97-223
Helical: 224-244
Lumenal: 245-335
Helical: 336-356
Cytoplasmic: 357-533
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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