Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2183) (CBMAB-T1288-YJ)

Name: Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2183)
SKU: CBMAB-T1288-YJ
Rating: 5 (1 reviews)

See all TBXAS1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-2183

Application

FC, ICC, IF, IHC, IHC-P, WB

Immunogen

Full length human recombinant protein of human TXA synthase (NP_001052) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Thromboxane A Synthase 1

Introduction

TBXAS1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, TBXAS1 is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. TBXAS1 plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke.

Entrez Gene ID

6916

UniProt ID

P24557

Alternative Names

Thromboxane A Synthase 1; Cytochrome P450, Family 5, Subfamily A, Polypeptide 1; Thromboxane A Synthase 1 (Platelet); Cytochrome P450 5A1; TXA Synthase; EC 5.3.99.5; CYP5A1; CYP5; TXS

Function

Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:8436233, PubMed:11297515, PubMed:9873013, PubMed:11097184, PubMed:24009185, PubMed:22735388).
Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:9873013, PubMed:22735388).
Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323).

Biological Process

Biological Process cellular chloride ion homeostasisIEA:Ensembl
Biological Process cyclooxygenase pathwayTAS:Reactome
Biological Process icosanoid metabolic processIDA:UniProtKB1 Publication
Biological Process positive regulation of vasoconstrictionIEA:Ensembl
Biological Process prostaglandin biosynthetic processIMP:UniProtKB1 Publication
Biological Process response to ethanolIEA:Ensembl
Biological Process response to fatty acidIEA:Ensembl

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Ghosal hematodiaphyseal dysplasia (GHDD):
Rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.

Topology

Cytoplasmic: 1-10
Helical: 11-31
Lumenal: 32-75
Helical: 76-96
Cytoplasmic: 97-223
Helical: 224-244
Lumenal: 245-335
Helical: 336-356
Cytoplasmic: 357-533

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2183)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2187) (CAT#: CBMAB-T1292-YJ)

Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2182) (CAT#: CBMAB-T1287-YJ)

Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2184) (CAT#: CBMAB-T1289-YJ)

Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2180) (CAT#: CBMAB-T1285-YJ)

Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2179) (CAT#: CBMAB-T1284-YJ)

Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2181) (CAT#: CBMAB-T1286-YJ)

Mouse Anti-TBXAS1 Recombinant Antibody (CBYJT-2185) (CAT#: CBMAB-T1290-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry