Mouse Anti-TCHH Recombinant Antibody (AE15) (CBMAB-T1411-YJ)

Name: Mouse Anti-TCHH Recombinant Antibody (AE15)
SKU: CBMAB-T1411-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

AE15

Application

WB, IHC-Fr, IHC-P

Immunogen

Urea-mercaptoethanol extract of human hair follicles

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS

Preservative

0.1% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Trichohyalin

Introduction

TCHH forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. TCHH also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene can cause uncombable hair syndrome.

Entrez Gene ID

Human	7062
Mouse	99681

UniProt ID

Human	Q07283
Mouse	A0A0B4J1F9

Alternative Names

Trichohyalin; TRHY; THH; THL; UHS3

Function

Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.

Biological Process

Biological Process intermediate filament organizationIBA:GO_Central1 Publication
Biological Process keratinizationIEA:UniProtKB-KW

Cellular Location

cornified envelope
cytoskeleton
cytosol

Involvement in disease

Uncombable hair syndrome 3 (UHS3):
A form of uncombable hair syndrome, a condition characterized by scalp hair that is impossible to comb due to the haphazard arrangement of the hair bundles. A characteristic morphologic feature is a triangular to reniform to heart shape on cross-sections, and a groove, canal or flattening along the entire length of the hair. Most individuals are affected early in childhood and the hair takes on a spun-glass appearance with the hair becoming dry, curly, glossy, lighter in color, and progressively uncombable. The hair growth rate can range from slow to normal, and the condition improves with age.

PTM

Substrate of transglutaminase. Some 200 arginines are probably converted to citrullines by peptidylarginine deimidase.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Human TCHH ELISA Kit (CAT#: V2LY-0626-LY3287)

Mouse Anti-Tchh Recombinant Antibody (CBYJT-2302) (CAT#: CBMAB-T1412-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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