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Mouse Anti-TCHH Recombinant Antibody (AE15) (CBMAB-T1411-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TCHH (Trichohyalin). The antibody can be used for immunoassay techniques, such as WB, IHC-Fr, IHC-P.
See all TCHH antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
AE15
Antibody Isotype
IgG
Application
WB, IHC-Fr, IHC-P

Basic Information

Immunogen
Urea-mercaptoethanol extract of human hair follicles
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.1% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Trichohyalin
Introduction
TCHH forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. TCHH also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene can cause uncombable hair syndrome.
Entrez Gene ID
Human7062
Mouse99681
UniProt ID
HumanQ07283
MouseA0A0B4J1F9
Alternative Names
Trichohyalin; TRHY; THH; THL; UHS3
Function
Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.
Biological Process
Biological Process intermediate filament organizationIBA:GO_Central1 Publication
Biological Process keratinizationIEA:UniProtKB-KW
Cellular Location
cornified envelope
cytoskeleton
cytosol
Involvement in disease
Uncombable hair syndrome 3 (UHS3):
A form of uncombable hair syndrome, a condition characterized by scalp hair that is impossible to comb due to the haphazard arrangement of the hair bundles. A characteristic morphologic feature is a triangular to reniform to heart shape on cross-sections, and a groove, canal or flattening along the entire length of the hair. Most individuals are affected early in childhood and the hair takes on a spun-glass appearance with the hair becoming dry, curly, glossy, lighter in color, and progressively uncombable. The hair growth rate can range from slow to normal, and the condition improves with age.
PTM
Substrate of transglutaminase. Some 200 arginines are probably converted to citrullines by peptidylarginine deimidase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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