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Mouse Anti-Tchh Recombinant Antibody (CBYJT-2302) (CBMAB-T1412-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Tchh (Trichohyalin). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all Tchh antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBYJT-2302
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 36-209 mapping at the N-terminus of Trichohyalin of mouse origin
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 36-209

Target

Full Name
Trichohyalin
Introduction
Tchh functions in intermediate filament organization.
Entrez Gene ID
Human7062
Mouse99681
Rat310588
UniProt ID
HumanQ07283
MouseA0A0B4J1F9
RatA0A0G2K862
Alternative Names
AHF; Thh; AI597080
Function
Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.
Biological Process
Biological Process intermediate filament organizationIBA:GO_Central1 Publication
Biological Process keratinizationIEA:UniProtKB-KW
Cellular Location
cornified envelope
cytoskeleton
cytosol
Involvement in disease
Uncombable hair syndrome 3 (UHS3):
A form of uncombable hair syndrome, a condition characterized by scalp hair that is impossible to comb due to the haphazard arrangement of the hair bundles. A characteristic morphologic feature is a triangular to reniform to heart shape on cross-sections, and a groove, canal or flattening along the entire length of the hair. Most individuals are affected early in childhood and the hair takes on a spun-glass appearance with the hair becoming dry, curly, glossy, lighter in color, and progressively uncombable. The hair growth rate can range from slow to normal, and the condition improves with age.
PTM
Substrate of transglutaminase. Some 200 arginines are probably converted to citrullines by peptidylarginine deimidase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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