Mouse Anti-Tchh Recombinant Antibody (CBYJT-2302) (CBMAB-T1412-YJ)

Name: Mouse Anti-Tchh Recombinant Antibody (CBYJT-2302)
SKU: CBMAB-T1412-YJ
Rating: 5 (1 reviews)

See all Tchh antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-2302

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 36-209 mapping at the N-terminus of Trichohyalin of mouse origin

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 36-209

More Infomation

Target

Full Name

Trichohyalin

Introduction

Tchh functions in intermediate filament organization.

Entrez Gene ID

Human	7062
Mouse	99681
Rat	310588

UniProt ID

Human	Q07283
Mouse	A0A0B4J1F9
Rat	A0A0G2K862

Alternative Names

AHF; Thh; AI597080

Function

Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.

Biological Process

Biological Process intermediate filament organizationIBA:GO_Central1 Publication
Biological Process keratinizationIEA:UniProtKB-KW

Cellular Location

cornified envelope
cytoskeleton
cytosol

Involvement in disease

Uncombable hair syndrome 3 (UHS3):
A form of uncombable hair syndrome, a condition characterized by scalp hair that is impossible to comb due to the haphazard arrangement of the hair bundles. A characteristic morphologic feature is a triangular to reniform to heart shape on cross-sections, and a groove, canal or flattening along the entire length of the hair. Most individuals are affected early in childhood and the hair takes on a spun-glass appearance with the hair becoming dry, curly, glossy, lighter in color, and progressively uncombable. The hair growth rate can range from slow to normal, and the condition improves with age.

PTM

Substrate of transglutaminase. Some 200 arginines are probably converted to citrullines by peptidylarginine deimidase.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-Tchh Recombinant Antibody (CBYJT-2302)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TCHH Recombinant Antibody (AE15) (CAT#: CBMAB-T1411-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry