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Mouse Anti-TCHP Recombinant Antibody (CBYJT-2303) (CBMAB-T1413-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TCHP (Trichoplein Keratin Filament Binding). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TCHP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2303
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Trichoplein Keratin Filament Binding
Introduction
TCHP (Trichoplein Keratin Filament Binding) is a Protein Coding gene. Diseases associated with TCHP include Vulvar Sarcoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments.
Entrez Gene ID
84260
UniProt ID
Q9BT92
Alternative Names
Trichoplein Keratin Filament Binding; Mitostatin; Mitochondrial Protein With Oncostatic Activity; Tumor Suppressor Protein; Trichoplein Keratin Filament-Binding Protein; Trichoplein, Keratin Filament Binding; Protein TCHP; TpMs
Function
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701).
Is a negative regulator of ciliogenesis (PubMed:25270598).
Biological Process
Biological Process apoptotic processIDA:UniProtKB1 Publication
Biological Process cell projection organizationIEA:UniProtKB-KW
Biological Process negative regulation of cell growthIDA:UniProtKB1 Publication
Biological Process negative regulation of cilium assemblyIMP:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm
Cell membrane
Mitochondrion
Cell junction, desmosome
PTM
Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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