Mouse Anti-TCHP Recombinant Antibody (CBYJT-2303) (CBMAB-T1413-YJ)

Name: Mouse Anti-TCHP Recombinant Antibody (CBYJT-2303)
SKU: CBMAB-T1413-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2303

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Trichoplein Keratin Filament Binding

Introduction

TCHP (Trichoplein Keratin Filament Binding) is a Protein Coding gene. Diseases associated with TCHP include Vulvar Sarcoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments.

Entrez Gene ID

84260

UniProt ID

Q9BT92

Alternative Names

Trichoplein Keratin Filament Binding; Mitostatin; Mitochondrial Protein With Oncostatic Activity; Tumor Suppressor Protein; Trichoplein Keratin Filament-Binding Protein; Trichoplein, Keratin Filament Binding; Protein TCHP; TpMs

Function

Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701).
Is a negative regulator of ciliogenesis (PubMed:25270598).

Biological Process

Biological Process apoptotic processIDA:UniProtKB1 Publication
Biological Process cell projection organizationIEA:UniProtKB-KW
Biological Process negative regulation of cell growthIDA:UniProtKB1 Publication
Biological Process negative regulation of cilium assemblyIMP:UniProtKB1 Publication

Cellular Location

Cytoplasm, cytoskeleton
Cytoplasm
Cell membrane
Mitochondrion
Cell junction, desmosome

PTM

Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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