TCHP

TCHP (Trichoplein Keratin Filament Binding) is a Protein Coding gene. Diseases associated with TCHP include Vulvar Sarcoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments.

Full Name

Trichoplein Keratin Filament Binding

Function

Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701).
Is a negative regulator of ciliogenesis (PubMed:25270598).

Biological Process

Biological Process apoptotic processIDA:UniProtKB1 Publication
Biological Process cell projection organizationIEA:UniProtKB-KW
Biological Process negative regulation of cell growthIDA:UniProtKB1 Publication
Biological Process negative regulation of cilium assemblyIMP:UniProtKB1 Publication

Cellular Location

Cytoplasm, cytoskeleton
Cytoplasm
Cell membrane
Mitochondrion
Cell junction, desmosome

PTM

Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis.