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Mouse Anti-TCIM Recombinant Antibody (373E1) (CBMAB-C5587-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
373E1
Antibody Isotype
IgG
Application
IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TCIM Gene(Protein Coding)


Transcriptional And Immune Response Regulator
Introduction
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
Entrez Gene ID
56892
UniProt ID
Q9NR00
Alternative Names
Transcriptional And Immune Response Regulator; Thyroid Cancer Protein 1; Human Thyroid Cancer 1; C8orf4; TC-1; TC1; Chromosome 8 Open Reading Frame 4; Protein C8orf4;
Function
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711).
Enhances the proliferation of follicular dendritic cells (PubMed:16730711).
Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821).
In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084).
Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013).
Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity).
In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347).
However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process cellular response to heatIDA:UniProtKB1 Publication
Biological Process endothelial cell activation involved in immune responseIDA:UniProtKB1 Publication
Biological Process negative regulation of apoptotic processIDA:CAFA1 Publication
Biological Process negative regulation of Notch signaling pathwayIDA:UniProtKB1 Publication
Biological Process positive regulation of NIK/NF-kappaB signalingIDA:UniProtKB1 Publication
Biological Process positive regulation of protein kinase A signalingIDA:CAFA1 Publication
Biological Process positive regulation of protein kinase C activityIDA:CAFA1 Publication
Biological Process regulation of cell cycle G1/S phase transitionIDA:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription in response to stressIDA:UniProtKB1 Publication
Biological Process regulation of hemopoiesisIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus, nucleolus
Nucleus speckle
Nucleus
Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001).
Translocates to the nucleus upon cellular stress such as H2O2 (PubMed:17603013).
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For research use only. Not intended for any clinical use.

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