TCIM

This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

Full Name

TCIM Gene(Protein Coding)

Transcriptional And Immune Response Regulator

Function

Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711).
Enhances the proliferation of follicular dendritic cells (PubMed:16730711).
Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821).
In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084).
Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013).
Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity).
In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347).
However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process cellular response to heatIDA:UniProtKB1 Publication
Biological Process endothelial cell activation involved in immune responseIDA:UniProtKB1 Publication
Biological Process negative regulation of apoptotic processIDA:CAFA1 Publication
Biological Process negative regulation of Notch signaling pathwayIDA:UniProtKB1 Publication
Biological Process positive regulation of NIK/NF-kappaB signalingIDA:UniProtKB1 Publication
Biological Process positive regulation of protein kinase A signalingIDA:CAFA1 Publication
Biological Process positive regulation of protein kinase C activityIDA:CAFA1 Publication
Biological Process regulation of cell cycle G1/S phase transitionIDA:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription in response to stressIDA:UniProtKB1 Publication
Biological Process regulation of hemopoiesisIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus, nucleolus
Nucleus speckle
Nucleus
Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001).
Translocates to the nucleus upon cellular stress such as H2O2 (PubMed:17603013).