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Mouse Anti-TCP11 Recombinant Antibody (CBYJT-2338) (CBMAB-T1453-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TCP11 (T-Complex 11). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TCP11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2338
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
TCP11 (NP_061149, 342-442aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 342-442

Target

Full Name
t-complex 11 homolog (mouse)
Introduction
TCP11 (T-Complex 11) plays a role in the process of sperm capacitation and acrosome reactions. It is a probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.
Entrez Gene ID
6954
UniProt ID
Q8WWU5
Alternative Names
T-Complex 11; Fertilization-Promoting Peptide Receptor; T-Complex 11 (A Murine Tcp Homolog); T-Complex 11, Testis-Specific; Testis Secretory Sperm-Binding Protein Li 222n; T-Complex Protein 11 Homolog
Function
Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.
Biological Process
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayISS:UniProtKB
Biological Process germ cell developmentIEP:UniProtKB1 Publication
Biological Process protein kinase A signalingISS:UniProtKB
Biological Process regulation of sperm capacitationISS:UniProtKB
Biological Process signal transductionIBA:GO_Central1 Publication
Biological Process spermatogenesisIEA:UniProtKB-KW
Cellular Location
Membrane
Cell projection, cilium, flagellum
Cytoplasmic vesicle, secretory vesicle, acrosome
Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm.
Topology
Helical: 330-349
PTM
Constitutively phosphorylated on serine, threonine and tyrosine residues within the head and tail regions of noncapacitated spermatozoa. Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal region in a protein kinase A (PKA)-dependent signaling pathway.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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