Rat Anti-Tdrd1 Recombinant Antibody (CBYJT-2460) (CBMAB-T1607-YJ)

Name: Rat Anti-Tdrd1 Recombinant Antibody (CBYJT-2460)
SKU: CBMAB-T1607-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rat

Clone

CBYJT-2460

Application

IHC

Immunogen

Recombinant protein corresponding to mouse TDRD1

Specificity

Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Tudor Domain Containing 1

Introduction

Tdrd1 plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. It is required for the localization of Piwi proteins to the meiotic nuage. It is Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. It may act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.

Entrez Gene ID

83561

UniProt ID

Q99MV1

Alternative Names

MTR-1; tudor domain-containing protein 1

Function

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).

Biological Process

Biological Process DNA methylation involved in gamete generationISS:UniProtKB
Biological Process gene silencing by RNAISS:UniProtKB
Biological Process germ cell developmentISS:UniProtKB
Biological Process meiotic cell cycleIEA:UniProtKB-KW
Biological Process P granule organizationIBA:GO_Central1 Publication
Biological Process piRNA metabolic processISS:UniProtKB
Biological Process spermatogenesisISS:UniProtKB

Cellular Location

Cytoplasm
Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rat Anti-Tdrd1 Recombinant Antibody (CBYJT-2461) (CAT#: CBMAB-T1608-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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