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Rat Anti-Tdrd1 Recombinant Antibody (CBYJT-2460) (CBMAB-T1607-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Tdrd1 (Tudor Domain Containing 1). The antibody can be used for immunoassay techniques, such as IHC.
See all Tdrd1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-2460
Antibody Isotype
IgG
Application
IHC

Basic Information

Immunogen
Recombinant protein corresponding to mouse TDRD1
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tudor Domain Containing 1
Introduction
Tdrd1 plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. It is required for the localization of Piwi proteins to the meiotic nuage. It is Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. It may act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.
Entrez Gene ID
83561
UniProt ID
Q99MV1
Alternative Names
MTR-1; tudor domain-containing protein 1
Function
Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).
Biological Process
Biological Process DNA methylation involved in gamete generationISS:UniProtKB
Biological Process gene silencing by RNAISS:UniProtKB
Biological Process germ cell developmentISS:UniProtKB
Biological Process meiotic cell cycleIEA:UniProtKB-KW
Biological Process P granule organizationIBA:GO_Central1 Publication
Biological Process piRNA metabolic processISS:UniProtKB
Biological Process spermatogenesisISS:UniProtKB
Cellular Location
Cytoplasm
Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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