TDRD1

Tdrd1 plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. It is required for the localization of Piwi proteins to the meiotic nuage. It is Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. It may act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.

Full Name

Tudor Domain Containing 1

Function

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).

Biological Process

Biological Process DNA methylation involved in gamete generationISS:UniProtKB
Biological Process gene silencing by RNAISS:UniProtKB
Biological Process germ cell developmentISS:UniProtKB
Biological Process meiotic cell cycleIEA:UniProtKB-KW
Biological Process P granule organizationIBA:GO_Central1 Publication
Biological Process piRNA metabolic processISS:UniProtKB
Biological Process spermatogenesisISS:UniProtKB

Cellular Location

Cytoplasm
Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity).