Rabbit Anti-TECPR1 Recombinant Antibody (CBYJT-2494) (CBMAB-T1643-YJ)

Name: Rabbit Anti-TECPR1 Recombinant Antibody (CBYJT-2494)
SKU: CBMAB-T1643-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBYJT-2494

Application

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TECPR1 Gene(Protein Coding) Tectonin Beta-Propeller Repeat Containing 1

Introduction

TECPR1 is a tethering factor involved in autophagy. TECPR1 is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy.

Entrez Gene ID

Human	25851
Mouse	70381
Rat	304285

UniProt ID

Human	Q7Z6L1
Mouse	Q80VP0
Rat	Q3ZBA0

Alternative Names

Tectonin Beta-Propeller Repeat Containing 1; KIAA1358

Function

Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.

Biological Process

Biological Process autophagosome maturationIMP:UniProtKB1 Publication
Biological Process autophagyIDA:UniProtKB1 Publication
Biological Process macroautophagyIMP:ComplexPortal1 Publication
Biological Process regulation of autophagosome maturationIMP:ComplexPortal1 Publication

Cellular Location

Cytoplasmic vesicle, autophagosome membrane
Lysosome membrane
Localizes to Lysosome membranes, and binds PtdIns3P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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