TECPR1

This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]

Full Name

TECPR1 Gene(Protein Coding) Tectonin Beta-Propeller Repeat Containing 1

Function

Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.

Biological Process

Biological Process autophagosome maturationIMP:UniProtKB1 Publication
Biological Process autophagyIDA:UniProtKB1 Publication
Biological Process macroautophagyIMP:ComplexPortal1 Publication
Biological Process regulation of autophagosome maturationIMP:ComplexPortal1 Publication

Cellular Location

Cytoplasmic vesicle, autophagosome membrane
Lysosome membrane
Localizes to Lysosome membranes, and binds PtdIns3P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.