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Mouse Anti-TESK1 Recombinant Antibody (1D11) (CBMAB-A9014-LY)

The product is antibody recognizes TESK1. The antibody 1D11 immunoassay techniques such as: WB, ELISA.
See all TESK1 antibodies
Published Data
Fig. 1 Lysates containing equal amounts of total protein from mouse tissues and cell lines were immunoprecipitated with rabbit anti-Spry2 or normal rabbit IgG as control. The resulting immunoprecipitates were separated on SDS-PAGE and blotted with anti-Tesk1 and anti-Spry2 as indicated.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D11
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TESK1 (AAH67130, 266 a.a. ~ 365 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TESK1 Gene(Protein Coding) Testis-Specific Kinase 1
Introduction
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. [provided by RefSeq]
Entrez Gene ID
7016
UniProt ID
Q15569
Function
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity).
Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity).
Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity).
Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898).
Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).
Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).
Biological Process
Biological Process actin cytoskeleton organizationSource:GO_Central1 Publication
Biological Process establishment of vesicle localizationSource:UniProtKB1 Publication
Biological Process negative regulation of cilium assemblySource:UniProtKB1 Publication
Biological Process negative regulation of phosphorylationSource:UniProtKB
Biological Process negative regulation of protein autophosphorylationSource:ARUK-UCLBy Similarity
Biological Process negative regulation of protein serine/threonine kinase activitySource:ARUK-UCLBy Similarity
Biological Process podocyte cell migrationSource:UniProtKB
Biological Process positive regulation of protein localization to nucleusSource:UniProtKB1 Publication
Biological Process positive regulation of protein phosphorylationSource:UniProtKB1 Publication
Biological Process positive regulation of stress fiber assemblySource:ARUK-UCLBy Similarity
Biological Process positive regulation of substrate adhesion-dependent cell spreadingSource:UniProtKB1 Publication
Biological Process regulation of actin cytoskeleton organizationSource:UniProtKB
Biological Process regulation of protein localizationSource:ARUK-UCLBy Similarity
Biological Process spermatogenesisSource:ProtInc1 Publication
PTM
Autophosphorylated on serine and tyrosine residues.
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For research use only. Not intended for any clinical use.

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