Rabbit Anti-TESK1 Recombinant Antibody (CBYJT-2557) (CBMAB-T1715-YJ)

Name: Rabbit Anti-TESK1 Recombinant Antibody (CBYJT-2557)
SKU: CBMAB-T1715-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBYJT-2557

Application

WB, IP

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TESK1 Gene(Protein Coding) Testis-Specific Kinase 1

Introduction

TESK1 is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). TESK1 can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.

Entrez Gene ID

7016

UniProt ID

Q15569

Alternative Names

Testis-Specific Kinase 1; Testicular Protein Kinase 1; Testis-Specific Kinase-1; Testis Specific Kinase-1; EC 2.7.12.1

Function

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity).
Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity).
Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity).
Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898).
Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).
Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).

Biological Process

Biological Process actin cytoskeleton organizationSource:GO_Central1 Publication
Biological Process establishment of vesicle localizationSource:UniProtKB1 Publication
Biological Process negative regulation of cilium assemblySource:UniProtKB1 Publication
Biological Process negative regulation of phosphorylationSource:UniProtKB
Biological Process negative regulation of protein autophosphorylationSource:ARUK-UCLBy Similarity
Biological Process negative regulation of protein serine/threonine kinase activitySource:ARUK-UCLBy Similarity
Biological Process podocyte cell migrationSource:UniProtKB
Biological Process positive regulation of protein localization to nucleusSource:UniProtKB1 Publication
Biological Process positive regulation of protein phosphorylationSource:UniProtKB1 Publication
Biological Process positive regulation of stress fiber assemblySource:ARUK-UCLBy Similarity
Biological Process positive regulation of substrate adhesion-dependent cell spreadingSource:UniProtKB1 Publication
Biological Process regulation of actin cytoskeleton organizationSource:UniProtKB
Biological Process regulation of protein localizationSource:ARUK-UCLBy Similarity
Biological Process spermatogenesisSource:ProtInc1 Publication

PTM

Autophosphorylated on serine and tyrosine residues.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-TESK1 Recombinant Antibody (1D11) (CAT#: CBMAB-A9014-LY)

Isotype control

For research use only. Not intended for any clinical use.

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