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Mouse Anti-TEX14 Recombinant Antibody (CBYJT-2600) (CBMAB-T1770-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TEX14 (Testis Expressed 14, Intercellular Bridge Forming Factor). The antibody can be used for immunoassay techniques, such as WB, IP, ELISA.
See all TEX14 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2600
Antibody Isotype
IgG
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
testis expressed 14
Introduction
TEX14 is necessary for intercellular bridges in germ cells, which are required for spermatogenesis.
Entrez Gene ID
56155
UniProt ID
Q8IWB6
Alternative Names
Testis Expressed 14, Intercellular Bridge Forming Factor; Testis-Expressed Sequence 14 Protein; Protein Kinase-Like Protein SgK307; Cancer/Testis Antigen 113; Sugen Kinase 307; Inactive Serine/Threonine-Protein Kinase TEX14; Testis Expressed Sequence 14
Function
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).
Biological Process
Biological Process attachment of spindle microtubules to kinetochoreSource:UniProtKB
Biological Process cell divisionSource:UniProtKB-KW
Biological Process cellular response to leukemia inhibitory factorSource:Ensembl
Biological Process intercellular bridge organizationSource:UniProtKB
Biological Process male meiotic nuclear divisionSource:UniProtKB
Biological Process mitotic sister chromatid separationSource:UniProtKB
Biological Process mitotic spindle assembly checkpoint signalingSource:UniProtKB
Biological Process negative regulation of cytokinesisSource:Ensembl
Biological Process negative regulation of protein bindingSource:Ensembl
Biological Process protein phosphorylationSource:InterPro
Cellular Location
Cytoplasm
Midbody
Chromosome, centromere, kinetochore
Detected in the intercellular bridges that connect male germ cell daughter cells after cell division.
Involvement in disease
Spermatogenic failure 23 (SPGF23):
An infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia.
PTM
Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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