TEX14

This gene is similar to a mouse gene that is expressed in the testis. [provided by RefSeq]

Full Name

testis expressed 14

Function

Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).

Biological Process

Biological Process attachment of spindle microtubules to kinetochoreSource:UniProtKB
Biological Process cell divisionSource:UniProtKB-KW
Biological Process cellular response to leukemia inhibitory factorSource:Ensembl
Biological Process intercellular bridge organizationSource:UniProtKB
Biological Process male meiotic nuclear divisionSource:UniProtKB
Biological Process mitotic sister chromatid separationSource:UniProtKB
Biological Process mitotic spindle assembly checkpoint signalingSource:UniProtKB
Biological Process negative regulation of cytokinesisSource:Ensembl
Biological Process negative regulation of protein bindingSource:Ensembl
Biological Process protein phosphorylationSource:InterPro

Cellular Location

Cytoplasm
Midbody
Chromosome, centromere, kinetochore
Detected in the intercellular bridges that connect male germ cell daughter cells after cell division.

Involvement in disease

Spermatogenic failure 23 (SPGF23):
An infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia.

PTM

Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.