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Mouse Anti-TFAM Recombinant Antibody (CBFYM-0072) (CBMAB-M0082-FY)

This product is mouse antibody that recognizes TFAM. The antibody CBFYM-0072 can be used for immunoassay techniques such as: WB, IHC-P, ICC, FC, ELISA.
See all TFAM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0072
Antibody Isotype
IgG2b
Application
WB, IHC-P, ICC, FC, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transcription factor A, mitochondrial
Introduction
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
7019
UniProt ID
Q00059
Alternative Names
Transcription Factor A, Mitochondrial; Mitochondrial Transcription Factor 1; Transcription Factor 6; TCF6L2; MTTF1; MTTFA; TCF6; Transcription Factor 6-Like 2 (Mitochondrial Transcription Factor); Mitochondrial Transcription Factor A
Function
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942).
Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603).
In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300).
Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172).
Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172).
Is able to unwind DNA (PubMed:22037172).
Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790).
Required for maintenance of normal levels of mitochondrial DNA (PubMed:22841477, PubMed:19304746).
May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171).
Biological Process
Biological Process mitochondrial respiratory chain complex assemblySource:Ensembl
Biological Process mitochondrial transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process transcription initiation at mitochondrial promoterSource:UniProtKB1 Publication
Cellular Location
Mitochondrion
Mitochondrion matrix, mitochondrion nucleoid
Involvement in disease
Mitochondrial DNA depletion syndrome 15, hepatocerebral type (MTDPS15):
An autosomal recessive mitochondrial disorder characterized by severe intrauterine growth restriction, neonatal-onset hypoglycemia and liver dysfunction, mitochondrial DNA depletion in liver and skeletal muscle, and abnormal mitochondrial morphology observed in skeletal muscle. Hepatic pathology includes cirrhosis, steatosis and cholestasis. Progression to liver failure and death is rapid with no evidence of neurological impairment or other organ involvement.
PTM
Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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