Mouse Anti-TFAM Recombinant Antibody (CBFYM-0072) (CBMAB-M0082-FY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603).
In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300).
Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172).
Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172).
Is able to unwind DNA (PubMed:22037172).
Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790).
Required for maintenance of normal levels of mitochondrial DNA (PubMed:22841477, PubMed:19304746).
May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171).
Biological Process mitochondrial transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process transcription initiation at mitochondrial promoterSource:UniProtKB1 Publication
Mitochondrion matrix, mitochondrion nucleoid
An autosomal recessive mitochondrial disorder characterized by severe intrauterine growth restriction, neonatal-onset hypoglycemia and liver dysfunction, mitochondrial DNA depletion in liver and skeletal muscle, and abnormal mitochondrial morphology observed in skeletal muscle. Hepatic pathology includes cirrhosis, steatosis and cholestasis. Progression to liver failure and death is rapid with no evidence of neurological impairment or other organ involvement.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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