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Mouse Anti-TFDP2 Recombinant Antibody (BC-2) (CBMAB-D2273-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
BC-2
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Immunogen
Recombinant DP2 protein (Human)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
TFDP2 belongs to transcription factor DP family. TFDP2 forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes.
Entrez Gene ID
7029
UniProt ID
Q14188
Alternative Names
Transcription Factor Dp-2; Transcription Factor Dp-2 (E2F Dimerization Partner 2); E2F Dimerization Partner 2; DP2;
Function
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Biological Process
Biological Process cell cycleSource:UniProtKB-KW
Biological Process heart developmentSource:Ensembl
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of cell cycleSource:InterPro
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Cellular Location
Nucleus
PTM
Ser-24 is probably phosphorylated by CDK2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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