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TFDP2

TFDP2 is a member of the transcription factor DP family. TFDP2 forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes.

Full Name

transcription factor Dp-2 (E2F dimerization partner 2)

Function

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Biological Process

Biological Process cell cycleSource:UniProtKB-KW
Biological Process heart developmentSource:Ensembl
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of cell cycleSource:InterPro
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication

Cellular Location

Nucleus

PTM

Ser-24 is probably phosphorylated by CDK2.

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Anti-TFDP2 antibodies

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Mouse Anti-TFDP2 Recombinant Antibody (CBYJT-2658) (CBMAB-T1839-YJ)

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Target: TFDP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2658

Application*: WB

Mouse Anti-TFDP2 Recombinant Antibody (CBYJT-2657) (CBMAB-T1837-YJ)

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Target: TFDP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2657

Application*: WB

Mouse Anti-TFDP2 Recombinant Antibody (CBYJT-2656) (CBMAB-T1836-YJ)

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Target: TFDP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-2656

Application*: E, WB

Mouse Anti-TFDP2 Recombinant Antibody (D-11) (CBMAB-D2274-YC)

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Target: TFDP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D-11

Application*: WB, IP, IF, E

Mouse Anti-TFDP2 Recombinant Antibody (BC-2) (CBMAB-D2273-YC)

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Target: TFDP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: BC-2

Application*: IP, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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