TFDP2

TFDP2 is a member of the transcription factor DP family. TFDP2 forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes.

transcription factor Dp-2 (E2F dimerization partner 2)

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Biological Process cell cycleSource:UniProtKB-KW
Biological Process heart developmentSource:Ensembl
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of cell cycleSource:InterPro
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication

Nucleus

Ser-24 is probably phosphorylated by CDK2.