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Mouse Anti-TFR2 Recombinant Antibody (CBYJT-2732) (CBMAB-T1921-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TFR2 (Transferrin Receptor 2). The antibody can be used for immunoassay techniques, such as WB.
See all TFR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2732
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human TFR2(NP_003218) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transferrin receptor 2
Introduction
TFR2 is a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. TFR2 mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in TFR2 have been associated with hereditary hemochromatosis type III.
Entrez Gene ID
7036
UniProt ID
Q9UP52
Alternative Names
Transferrin Receptor 2; Transferrin Receptor Protein 2; TFRC2; HFE3; TfR2
Function
Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Biological Process
Biological Process acute-phase responseSource:Ensembl
Biological Process cellular iron ion homeostasisSource:UniProtKB1 Publication
Biological Process cellular response to iron ionSource:BHF-UCL1 Publication
Biological Process endocytic iron import into cellSource:BHF-UCL2 Publications
Biological Process iron ion homeostasisSource:BHF-UCL1 Publication
Biological Process iron ion transportSource:UniProtKB1 Publication
Biological Process positive regulation of endocytosisSource:BHF-UCL1 Publication
Biological Process positive regulation of peptide hormone secretionSource:BHF-UCL1 Publication
Biological Process positive regulation of protein maturationSource:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:BHF-UCL1 Publication
Biological Process receptor-mediated endocytosisSource:BHF-UCL1 Publication
Biological Process response to iron ionSource:BHF-UCL1 Publication
Biological Process transferrin transportSource:BHF-UCL1 Publication
Cellular Location
Cell membrane
Isoform Beta
Cytoplasm
Lacks the transmembrane domain. Probably intracellular.
Involvement in disease
Hemochromatosis 3 (HFE3):
A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.
Topology
Cytoplasmic: 1-83
Helical: 84-104
Extracellular: 105-801
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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