Mouse Anti-TFR2 Recombinant Antibody (CBYJT-2733) (CBMAB-T1922-YJ)

Name: Mouse Anti-TFR2 Recombinant Antibody (CBYJT-2733)
SKU: CBMAB-T1922-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2733

Application

ELISA

Immunogen

TFR2 (NP_003218, 631 a.a. ~ 731 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: IRLSHDRLLP LDFGRYGDVV LRHIGNLNEF SGDLKARGLT LQWVYSARGD YIRAAEKLRQ EIYSSEERDE RLTRMYNVRI MRVEFYFLSQ YVSPADSPFR *

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 631-731

More Infomation

Target

Full Name

transferrin receptor 2

Introduction

TFR2 is a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. TFR2 mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in TFR2 have been associated with hereditary hemochromatosis type III.

Entrez Gene ID

7036

UniProt ID

Q9UP52

Alternative Names

Transferrin Receptor 2; Transferrin Receptor Protein 2; TFRC2; HFE3; TfR2

Function

Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.

Biological Process

Biological Process acute-phase responseSource:Ensembl
Biological Process cellular iron ion homeostasisSource:UniProtKB1 Publication
Biological Process cellular response to iron ionSource:BHF-UCL1 Publication
Biological Process endocytic iron import into cellSource:BHF-UCL2 Publications
Biological Process iron ion homeostasisSource:BHF-UCL1 Publication
Biological Process iron ion transportSource:UniProtKB1 Publication
Biological Process positive regulation of endocytosisSource:BHF-UCL1 Publication
Biological Process positive regulation of peptide hormone secretionSource:BHF-UCL1 Publication
Biological Process positive regulation of protein maturationSource:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:BHF-UCL1 Publication
Biological Process receptor-mediated endocytosisSource:BHF-UCL1 Publication
Biological Process response to iron ionSource:BHF-UCL1 Publication
Biological Process transferrin transportSource:BHF-UCL1 Publication

Cellular Location

Cell membrane
Isoform Beta
Cytoplasm
Lacks the transmembrane domain. Probably intracellular.

Involvement in disease

Hemochromatosis 3 (HFE3):
A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.

Topology

Cytoplasmic: 1-83
Helical: 84-104
Extracellular: 105-801

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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