Sign in or Register   Sign in or Register
  |  

Mouse Anti-Tgm1 Recombinant Antibody (CBYJT-2850) (CBMAB-T2076-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Tgm1 (Transglutaminase 1). The antibody can be used for immunoassay techniques, such as WB.
See all Tgm1 antibodies

Summary

Host Animal
Mouse
Specificity
Guinea pig
Clone
CBYJT-2850
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Recombinant bacterial transglutaminase from Streptomyces mobaraensis
Specificity
Guinea pig
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TGM1 Gene(Protein Coding) Transglutaminase 1
Introduction
Tgm1 functions in processes such as keratinocyte differentiation, peptide cross-linking, positive regulation of cell cycle, positive regulation of keratinocyte proliferation.
Entrez Gene ID
100724400
UniProt ID
A0A286XL02
Function
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141).
Biological Process
Biological Process cell envelope organizationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process keratinizationIEA:UniProtKB-KW
Biological Process keratinocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Biological Process positive regulation of cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of keratinocyte proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein modification process1 PublicationNAS:UniProtKB
Cellular Location
Membrane
Involvement in disease
Ichthyosis, congenital, autosomal recessive 1 (ARCI1):
A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.
PTM
Palmitoylated.
The membrane anchorage region possesses a cluster of five cysteines within which fatty acid(s) may become thioester-linked. It is subject to phorbol ester-stimulated phosphorylation and is hypersensitive to proteolysis, which releases the enzyme in a soluble form.
Tyrosine-phosphorylated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-Tgm1 Recombinant Antibody (CBYJT-2850)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare