Mouse Anti-TGM1 Recombinant Antibody (CBYJT-2852) (CBMAB-T2078-YJ)

Name: Mouse Anti-TGM1 Recombinant Antibody (CBYJT-2852)
SKU: CBMAB-T2078-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2852

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Immunogen

Transglutaminase 1, Keratinocyte

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TGM1 Gene(Protein Coding) Transglutaminase 1

Introduction

TGM1 is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in it. TGM1 alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).

Entrez Gene ID

7051

UniProt ID

P22735

Alternative Names

Transglutaminase 1; K Polypeptide Epidermal Type I, Protein-Glutamine-Gamma-Glutamyltransferase; Transglutaminase K; Epidermal TGase; EC 2.3.2.13; TGase K; TGase-1; TG(K); KTG; TGK; Transglutaminase 1 (K Polypeptide Epidermal Type I, Protein-Glutamine-Gamma-Glutamyltransferase)

Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141).

Biological Process

Biological Process cell envelope organizationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process keratinizationIEA:UniProtKB-KW
Biological Process keratinocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Biological Process positive regulation of cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of keratinocyte proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein modification process1 PublicationNAS:UniProtKB

Cellular Location

Membrane

Involvement in disease

Ichthyosis, congenital, autosomal recessive 1 (ARCI1):
A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.

PTM

Palmitoylated.
The membrane anchorage region possesses a cluster of five cysteines within which fatty acid(s) may become thioester-linked. It is subject to phorbol ester-stimulated phosphorylation and is hypersensitive to proteolysis, which releases the enzyme in a soluble form.
Tyrosine-phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TGM1 Matched Antibody Pair (1202) (CAT#: APMAB-1202LY)

Related Products

TGM1 Matched Antibody Pair (1202) (CAT#: APMAB-1202LY)

Mouse Anti-TGM1 Recombinant Antibody (CBYJT-2851) (CAT#: CBMAB-T2077-YJ)

Mouse Anti-Tgm1 Recombinant Antibody (CBYJT-2850) (CAT#: CBMAB-T2076-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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