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Mouse Anti-THBD Recombinant Antibody (CBT4208) (V2LY-0625-LY1099)


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Tested Data
Mouse Anti-THBD Recombinant Antibody (CBT4208) (V2LY-0625-LY1099) in ELISA
Mouse Anti-THBD Recombinant Antibody (CBT4208) (V2LY-0625-LY1099) in ELISA
Mouse Anti-THBD Recombinant Antibody (CBT4208) (V2LY-0625-LY1099) in WB
Mouse Anti-THBD Recombinant Antibody (CBT4208) (V2LY-0625-LY1099) in WB
Mouse Anti-THBD Recombinant Antibody (CBT4208) (V2LY-0625-LY1099) in WB
Mouse Anti-THBD Recombinant Antibody (CBT4208) (V2LY-0625-LY1099) in WB
Mouse Anti-THBD Recombinant Antibody (CBT4208) (V2LY-0625-LY1099) in FC
Mouse Anti-THBD Recombinant Antibody (CBT4208) (V2LY-0625-LY1099) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4208
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD141 (AA: extra 297-505) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
7056
Function
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Biological Process
Biological Process blood coagulationSource:ProtInc1 Publication
Biological Process blood coagulation, common pathwaySource:ComplexPortal1 Publication
Biological Process female pregnancySource:Ensembl
Biological Process negative regulation of blood coagulationSource:BHF-UCL1 Publication
Biological Process negative regulation of fibrinolysisSource:BHF-UCL1 Publication
Biological Process negative regulation of platelet activationSource:BHF-UCL1 Publication
Biological Process proteolysisSource:ComplexPortal1 Publication
Biological Process response to cAMPSource:Ensembl
Biological Process response to lipopolysaccharideSource:Ensembl
Biological Process response to X-raySource:Ensembl
Biological Process zymogen activationSource:ComplexPortal1 Publication
Cellular Location
Membrane
Involvement in disease
Thrombophilia due to thrombomodulin defect (THPH12):
A hemostatic disorder characterized by a tendency to thrombosis.
Hemolytic uremic syndrome atypical 6 (AHUS6):
An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
Topology
Extracellular: 19-515
Helical: 516-539
Cytoplasmic: 540-575
PTM
N-glycosylated.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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