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Mouse Anti-THRAP3 Recombinant Antibody (CBYJT-3034) (CBMAB-T2288-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to THRAP3 (Thyroid Hormone Receptor Associated Protein 3). The antibody can be used for immunoassay techniques, such as WB, IP, IF, IHC-P, ELISA.
See all THRAP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3034
Antibody Isotype
IgG
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Thyroid Hormone Receptor Associated Protein 3
Introduction
THRAP3 (Thyroid Hormone Receptor Associated Protein 3) is a Protein Coding gene. Diseases related to THRAP3 include Wilms Tumor 1. Among its related pathways are PEDF Induced Signaling and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to THRAP3 include transcription coactivator activity. An important paralog of THRAP3 is BCLAF1.
Entrez Gene ID
9967
UniProt ID
Q9Y2W1
Alternative Names
Thyroid Hormone Receptor Associated Protein 3; BCLAF1 And THRAP3 Family Member 2; Thyroid Hormone Receptor-Associated Protein Complex 150 KDa Component; TR-Associated Protein, 150-KDa; TRAP150; BCLAF2; Thyroid Hormone Receptor-Associated Protein, 150 KDa Subunit; Thyroid Hormone Receptor-Associated Protein 3
Function
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
Biological Process
Biological Process circadian rhythmSource:Ensembl
Biological Process mRNA processingSource:UniProtKB-KW
Biological Process mRNA stabilizationSource:UniProtKB1 Publication
Biological Process nuclear-transcribed mRNA catabolic processSource:UniProtKB1 Publication
Biological Process positive regulation of circadian rhythmSource:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of mRNA splicing, via spliceosomeSource:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:MGI1 Publication
Biological Process regulation of alternative mRNA splicing, via spliceosomeSource:UniProtKB1 Publication
Biological Process RNA splicingSource:UniProtKB-KW
Cellular Location
Nucleus
Nucleus, nucleoplasm
Nucleus speckle
PTM
ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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